Process Tools

Batch Chromatography

Batch chromatography: a single column fed a sequence of operation steps — inject, then elute, then wash — with the outlet composition traced over time. Components separate because the more strongly adsorbed one moves down the column more slowly, so it leaves later. For continuous separation of the same mixture see the SMB and TMB simulators.

The injection has to be narrower than the gap between two peaks, or they elute together however good the column is — the panel shows that gap and refuses a run that cannot resolve.

Run a simulation to see results

Results

Set up a column and step sequence, then run a simulation.

Column & method

Load:
10.20
20.50

Operation steps

Step 1 — injection
Step 2
Solver tolerances

Both default to 1e-4, which is what the reference solver uses. Loosen them if a run fails to integrate; tighten them to check a result is not an artefact of the tolerance.

120 intervals over 12.2 min · peaks ~1.77 min apart